Recognising the importance and impact of Imaging Scientists: Global guidelines for establishing career paths within core facilities.

In the dynamic landscape of scientific research, imaging core facilities are vital hubs propelling collaboration and innovation at the technology development and dissemination frontier. Here, we present a collaborative effort led by Global BioImaging (GBI), introducing international recommendations geared towards elevating the careers of Imaging Scientists in core facilities. Despite the critical role of Imaging Scientists in modern research ecosystems, challenges persist in recognising their value, aligning performance metrics and providing avenues for career progression and job security. The challenges encompass a mismatch between classic academic career paths and service-oriented roles, resulting in a lack of understanding regarding the value and impact of Imaging Scientists and core facilities and how to evaluate them properly. They further include challenges around sustainability, dedicated training opportunities and the recruitment and retention of talent. Structured across these interrelated sections, the recommendations within this publication aim to propose globally applicable solutions to navigate these challenges. These recommendations apply equally to colleagues working in other core facilities and research institutions through which access to technologies is facilitated and supported. This publication emphasises the pivotal role of Imaging Scientists in advancing research programs and presents a blueprint for fostering their career progression within institutions all around the world.

Big data in contemporary electron microscopy: challenges and opportunities in data transfer, compute and management.

The second decade of the twenty-first century witnessed a new challenge in the handling of microscopy data. Big data, data deluge, large data, data compliance, data analytics, data integrity, data interoperability, data retention and data lifecycle are terms that have introduced themselves to the electron microscopy sciences. This is largely attributed to the booming development of new microscopy hardware tools. As a result, large digital image files with an average size of one terabyte within one single acquisition session is not uncommon nowadays, especially in the field of cryogenic electron microscopy. This brings along numerous challenges in data transfer, compute and management. In this review, we will discuss in detail the current state of international knowledge on big data in contemporary electron microscopy and how big data can be transferred, computed and managed efficiently and sustainably. Workflows, solutions, approaches and suggestions will be provided, with the example of the latest experiences in Australia. Finally, important principles such as data integrity, data lifetime and the FAIR and CARE principles will be considered.

Proposed Implementation of a Patient-Centered Self-Assessment Tool for Patients with Neuroendocrine Tumors among Academic and Community Practice Sites: The City of Hope Model.

Neuroendocrine tumors are a rare type of cancer found in hormone-producing cells throughout the body. Research on disease-specific patient education assessments in this population is lacking. We previously demonstrated the feasibility and validity of NET VITALS, a patient-centered self-assessment designed to improve patients' knowledge of their neuroendocrine tumor diagnosis/treatment and facilitate communication with their physician. In this report, we provide a brief overview of patient assessments that have been used for patients with neuroendocrine tumors. We summarize NET VITALS and present a proposed infrastructure for its implementation into standard clinical care in both academic and community practice settings at City of Hope. Incorporating NET VITALS into standard of care treatment for patients with neuroendocrine tumors may improve patients' overall clinical care experience.

Effects of Health and Wellness Coaching With an Adult Cancer Caregiver.

Introduction Although cancer most directly affects the patient, its impact is also widely recognized to extend to those who are caring for the patient. Cancer patient caregivers endure psychological distress, have high levels of depression, and report isolation and strain. Research on targeted caregiver interventions is limited. This case report examines the use of health and wellness coaching (HWC) with a caregiver of a patient with neuroendocrine tumors, a rare, insidious type of cancer. Case Presentation We present the first known case report on using HWC with a 44-year-old woman adult cancer patient caregiver who was caring for a patient with neuroendocrine tumors. The patient had a chronically elevated body mass index, cholesterol, and stage 2 hypertension. Her primary care physician had prescribed weight loss medication (naltrexone/bupropion), which the patient hesitated to take and wanted to try HWC instead. The 10-session intervention targeted multiple components of health, including blood pressure, body mass index, cholesterol, weight loss, stress management, relationship success, and vocational progress. Outcomes were followed over a 1-year period. Conclusion This case demonstrates multiple unique aspects of the HWC process that support successful, sustainable behavioral change. The case patient's success suggests HWC may be effective in supporting beneficial physical and psychosocial outcomes with an adult cancer caregiver and should be considered a viable option for promoting health in caregivers.

MyScope: Free online microscopy training resource - continuing development to reflect the current microscopy landscape.

The MyScope online training resource has been supporting the global microscopy community since 2011. Since then, it has expanded from six to twelve modules, growing in line with emerging and increasingly important areas of microscopy such as FIB and Cryo-EM. By sharing the expertise and commitment of Microscopy Australia staff to effective and efficient microscopy training, MyScope is being maintained as an up-to-date training tool. Online teaching and training resources such as MyScope have proven to be more important than ever in helping facilities and course leaders manage pandemic-impacted teaching, training and access regimes.

Feasibility and Satisfaction of Using NET VITALS Self-assessment Tool Among Patients With Neuroendocrine Tumors.

OBJECTIVES: There is a lack of effective patient education regarding diagnosis/treatment of neuroendocrine tumors (NETs), possibly related to their rare incidence. METHODS: In this cross-sectional survey study, NET patients attending the 2019 Annual Los Angeles NET Education Conference were approached to complete NET VITALS, a self-assessment tool gauging patients' perception/awareness of their NET diagnosis/treatment, and a satisfaction survey. Feasibility of NET VITALS, patient satisfaction with NET VITALS, and patients' perception/awareness of their NET diagnosis/treatment were evaluated. RESULTS: This analysis included 68 patients (median age, 63 years; 47.1% gastrointestinal NETs; 88.2% metastatic disease). Participation was 88.3% (68/77), with a median of 85.7% of items completed (range, 61.9%-100.0%). More than 30% of the patients answered "Don't know/Not familiar"/left blank questions related to tumor characteristics, years of symptoms, and liver-directed therapies. In addition, 69.5% of the patients did not feel sufficient information about NETs was provided at diagnosis. Overall, 67.8% of the patients felt that NET VITALS provides topics to discuss with providers and 76.3% would recommend NET VITALS to others. CONCLUSIONS: NET VITALS is a feasible and acceptable self-assessment tool to potentially help patients improve communication about their NET diagnosis/treatment with their physician. Further studies will examine NET VITALS' generalizability and discuss its incorporation into clinical care.

Is the orthographic/phonological onset a single unit in reading aloud?

Two main theories of visual word recognition have been developed regarding the way orthographic units in printed words map onto phonological units in spoken words. One theory suggests that a string of single letters or letter clusters corresponds to a string of phonemes (Coltheart, 1978; Venezky, 1970), while the other suggests that a string of single letters or letter clusters corresponds to coarser phonological units, for example, onsets and rimes (Treiman & Chafetz, 1987). These theoretical assumptions were critical for the development of coding schemes in prominent computational models of word recognition and reading aloud. In a reading-aloud study, we tested whether the human reading system represents the orthographic/phonological onset of printed words and nonwords as single units or as separate letters/phonemes. Our results, which favored a letter and not an onset-coding scheme, were successfully simulated by the dual-route cascaded (DRC) model (Coltheart, Rastle, Perry, Langdon, & Ziegler, 2001). A separate experiment was carried out to further adjudicate between 2 versions of the DRC model.

Phonological encoding in the attentional blink paradigm.

The attentional blink refers to a deficit in reporting a second target that follows a first target within a few hundred milliseconds, when both targets occur in a sequence of distractors shown serially at rates of about 10 items per second. In four experiments, phonological similarity of post-Target 1 distractors impaired dual target report within the interval in which the attentional blink occurs. Similarity of letter targets had a smaller, less reliable effect on performance. Phonological similarity of letter distractors did not affect single target identification (Experiment 3), but it continued to impair dual target report (Experiment 5), even when the targets belonged to a different category-namely, digits. The results demonstrated that, not only targets, but also distractors are encoded phonologically, despite the fact that distractors are irrelevant and never have to be reported.